Author: Nikola Benin
In recent years, worldwide and in Kazakhstan, the number of patients with asthma and chronic obstructive pulmonary disease (COPD) progressively increases.
Patients with asthma have increase of CD4 + T-lymphocytes in the airways, mainly T-helper 2 cells (Th2), with the corresponding production of cytokines. In bronchial biopsies, small airways and lung parenchyma of patients with COPD is detected infiltration by T cells (predominantly Th1 and cytotoxic cells), increased numbers of neutrophils and macrophages.
Regions with a wide range of natural and man-made pollutant impacts on the environment provide opportunities for epigenetic research.
In the planned study, markers of exposure to pollutants, polymorphic variants of genes, DNA modification of histone proteins, the expression of specific miRNAs in immune cells will be studied in a healthy population, patients with asthma and COPD.